Role of the Nlrp3 Inflammasome in Microbial Infection

Frontiers in Cellular and Infection Microbiology

Paras K Anand¹  Thirumala-Devi eKanneganti¹  R.K. Subbarao eMalireddi¹ 

[1] St Jude Children's Research Hospital;

关键词: IL-1β;    NLRP3;    Inflammasome;    caspase-1;    NLR;    IL-18;   

DOI  :  10.3389/fmicb.2011.00012

来源: DOAJ

【 摘 要 】

The intracellular Nod-like receptor Nlrp3 has emerged as the most versatile innate immune receptor because of its broad specificity in mediating immune response to a wide range of microbial or danger signals. Nlrp3 mediates assembly of the inflammasome complex in the presence of microbial components leading to the activation of caspase-1 and the processing and release of the pro-inflammatory cytokines IL-1β and IL-18. In this review, we give an update on the recent literature examining the role of Nlrp3 inflammasome in response to fungal, bacterial and viral infections.

【 授权许可】

Unknown