Structures and functions of the inflammasome engine

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:147

Review

Wang, Longfei^1,2  Sharif, Humayun^1,2  Vora, Setu M.^1,2  Zheng, Yumei^1,2  Wu, Hao^1,2 

[1] Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[2] Boston Childrens Hosp, Program Cellular & Mol Med, 3 Blackfan Circle, Boston, MA 02115 USA

关键词: Inflammasome;    NLRP3;    NLRP1;    NLRC4;    pyroptosis;    IL-1;    caspase-1;   

DOI  :  10.1016/j.jaci.2021.04.018

来源: Elsevier

【 摘 要 】

Inflammasomes are molecular machines that carry out inflammatory responses on challenges by pathogens and endogenous dangers. Dysregulation of inflammasome assembly and regulation is associated with numerous human diseases from autoimmunity to cancer. In recent years, significant advances have been made in understanding the mechanism of inflammasome signaling using structural approaches. Here, we review inflammasomes formed by the NLRP1, NLRP3, and NLRC4 sensors, which are well characterized structurally, and discuss the structural and functional diversity among them.

【 授权许可】

Free