Production of a novel multi-epitope vaccine based on outer membrane proteins of Klebsiella pneumoniae

Trends in Pharmaceutical Sciences

关键词: klebsiella pneumoniae;    multi-epitope vaccine;    production;   

DOI  :  

来源: DOAJ

【 摘 要 】

Klebsiella pneumoniae is a hospital-acquired pathogen that leads to various infections. Hence, efforts to develop an effective vaccine against that pathogen are well documented. Our interest is the production of the previously designed multi-epitope vaccine construct against the K. pneumoniae in a prokaryotic host. Therefore, a new construct containing the nucleotide sequence of the novel vaccine was successfully expressed in Escherichia coli and then purified by Ni-NTA spin column. The purified recombinant protein can be considered as potential vaccine candidate for wet-laboratory analysis aiming to fight K pneumoniae .

【 授权许可】

Unknown