A Convolutional Neural Network Deep Learning Model Trained on CD Ulcers Images Accurately Identifies NSAID Ulcers

Frontiers in Medicine

Fergus Shanahan¹  Martin Buckley²  Brynjulf Mortensen³  Anders Damholt³  Shelly Soffer⁴  Yiftach Barash⁴  Eyal Klang⁴  Eli Konen⁵  Reuma Margalit Yehuda⁶  Rami Eliakim⁶  Uri Kopylov⁶  Ana Grinman⁶  Shomron Ben-Horin⁶ 

[1] APC Microbiome Ireland, Cork, Ireland;Centre for Gastroenterology, Mercy University Hospital, Cork, Ireland;Chr. Hansen A/S, Human Health Innovation, Hoersholm, Denmark;Deep Vision Lab, Sheba Medical Center, Tel Hashomer, Israel;Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Affiliated to Sackler Medical School, Tel Aviv University, Tel Aviv, Israel;Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Affiliated to Sackler Medical School, Tel Aviv University, Tel Aviv, Israel;

关键词: deep learning;    capsule endoscopy;    Crohn disease;    anti-inflammatory agents;    non-steroidal;    NSAID;   

DOI  :  10.3389/fmed.2021.656493

来源: DOAJ

【 摘 要 】

Background and Study Aims: Deep learning (DL) for video capsule endoscopy (VCE) is an emerging research field. It has shown high accuracy for the detection of Crohn's disease (CD) ulcers. Non-steroidal anti-inflammatory drugs (NSAIDS) are commonly used medications. In the small bowel, NSAIDs may cause a variety of gastrointestinal adverse events including NSAID-induced ulcers. These ulcers are the most important differential diagnosis for small bowel ulcers in patients evaluated for suspected CD. We evaluated a DL network that was trained using CD VCE ulcer images and evaluated its performance for NSAID ulcers.Patients and Methods: The network was trained using CD ulcers and normal mucosa from a large image bank created from VCE of diagnosed CD patients. NSAIDs-induced enteropathy images were extracted from the prospective Bifidobacterium breve (BIf95) trial dataset. All images were acquired from studies performed using PillCam SBIII. The area under the receiver operating curve (AUC) was used as a metric. We compared the network's AUC for detecting NSAID ulcers to that of detecting CD ulcers.Results: Overall, the CD training dataset included 17,640 CE images. The NSAIDs testing dataset included 1,605 CE images. The DL network exhibited an AUC of 0.97 (95% CI 0.97–0.98) for identifying images with NSAID mucosal ulcers. The diagnostic accuracy was similar to that obtained for CD related ulcers (AUC 0.94–0.99).Conclusions: A network trained on VCE CD ulcers similarly identified NSAID findings. As deep learning is transforming gastrointestinal endoscopy, this result should be taken into consideration in the future design and analysis of VCE deep learning applications.

【 授权许可】

Unknown