Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses

Acta Pharmaceutica Sinica B

Jesse K. Fletcher¹  Tony Y. Hu¹  Wenfu Tang²  Meihua Wan³  Christopher J. Lyon³  Qian Hu⁴ 

[1] Department of Biochemistry &Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA;Center of Cellular and Molecular Diagnosis, Tulane University School of Medicine, New Orleans, LA 70112, USA;Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China;

关键词: Extracellular vesicles;    Macrophage;    Tissue injury;    Inflammatory disease;    Interaction loop;    Stem cell;   

DOI  :  

来源: DOAJ

【 摘 要 】

Macrophages are typically identified as classically activated (M1) macrophages and alternatively activated (M2) macrophages, which respectively exhibit pro- and anti-inflammatory phenotypes, and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation, injury, and repair processes. Recent studies indicate that tissue cells and macrophages interact via the release of small extracellular vesicles (EVs) in processes where EVs released by stressed tissue cells can promote the activation and polarization of adjacent macrophages which can in turn release EVs and factors that can promote cell stress and tissue inflammation and injury, and vice versa. This review discusses the roles of such EVs in regulating such interactions to influence tissue inflammation and injury in a number of acute and chronic inflammatory disease conditions, and the potential applications, advantage and concerns for using EV-based therapeutic approaches to treat such conditions, including their potential role of drug carriers for the treatment of infectious diseases.

【 授权许可】

Unknown