Efficacy and Safety Evaluation of a Chlorine Dioxide Solution

International Journal of Environmental Research and Public Health

Shan-Shue Wang¹  Tzong-Der Way²  Jung-Yie Kao²  Chun-Wei Peng³  Ming-Long Cheng³  Hao-Chang Yin³  Bin-Syuan Huang³  Chu-Wei Hsu³  Jui-Wen Ma³ 

[1] Department of Applied Cosmetology/Degree Program of Cosmetology and Health Care, Kao Yuan University, No. 1821, Zhongshan Road, Lujhu District, Kaohsiung 82151, Taiwan;Institute of Biochemistry, College of Life Science, National Chung Hsing University, No. 145 Xingda Road, South District, Taichung 402, Taiwan;Unique Biotech Co., Ltd., Rm. 1, 22 F, No. 56, Minsheng 1st Road, Xinxing District, Kaohsiung 800, Taiwan;

关键词: chlorine dioxide (PubChem CID: 24870);    antimicrobial efficacy;    antiviral assay;    inhalation toxicity;    subchronic oral toxicity;   

DOI  :  10.3390/ijerph14030329

来源: DOAJ

【 摘 要 】

In this study, a chlorine dioxide solution (UC-1) composed of chlorine dioxide was produced using an electrolytic method and subsequently purified using a membrane. UC-1 was determined to contain 2000 ppm of gaseous chlorine dioxide in water. The efficacy and safety of UC-1 were evaluated. The antimicrobial activity was more than 98.2% reduction when UC-1 concentrations were 5 and 20 ppm for bacteria and fungi, respectively. The half maximal inhibitory concentrations (IC50) of H1N1, influenza virus B/TW/71718/04, and EV71 were 84.65 ± 0.64, 95.91 ± 11.61, and 46.39 ± 1.97 ppm, respectively. A 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test revealed that the cell viability of mouse lung fibroblast L929 cells was 93.7% at a 200 ppm UC-1 concentration that is over that anticipated in routine use. Moreover, 50 ppm UC-1 showed no significant symptoms in a rabbit ocular irritation test. In an inhalation toxicity test, treatment with 20 ppm UC-1 for 24 h showed no abnormality and no mortality in clinical symptoms and normal functioning of the lung and other organs. A ClO2 concentration of up to 40 ppm in drinking water did not show any toxicity in a subchronic oral toxicity test. Herein, UC-1 showed favorable disinfection activity and a higher safety profile tendency than in previous reports.

【 授权许可】

Unknown