A rare case of prostatic ductal adenocarcinoma presenting as papillary metastatic carcinoma of unknown primary: A case report and review of the literature

Human Pathology: Case Reports

Ximing J. Yang, MD, PhD¹  Erik R. Washburn, MD²  Grace W. Weyant, MD²  Zhaohai Yang, MD, PhD² 

[1] Department of Pathology, Northwestern University, Chicago, IL;Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA;

关键词: Prostatic neoplasms;    Ductal carcinoma;    Unknown primary neoplasms;    Neoplasm metastasis;   

DOI  :  10.1016/j.ehpc.2015.12.004

来源: DOAJ

【 摘 要 】

Prostatic ductal adenocarcinoma is an uncommon form of prostatic carcinoma. We report a case of a 63-year-old man who presented with non-infective thrombotic (marantic) endocarditis and an incidental finding of a destructive lesion in the left iliac crest. Core biopsy of the lesion showed a carcinoma with papillary architecture and was initially diagnosed as “metastatic carcinoma of unknown origin”. The patient experienced a cerebral infarction and expired six days later. Postmortem examination revealed extensive mixed acinar and ductal adenocarcinoma (Gleason score 5 + 4 = 9) in the prostate. Further studies confirmed the bone lesion as metastatic prostatic ductal adenocarcinoma. Although rare, metastatic prostatic adenocarcinoma should be considered in the differential diagnosis in a male patient when the carcinoma shows predominantly papillary architectures. A review of literature is presented to enhance the awareness of this entity.

【 授权许可】

Unknown