Drought’s potential influence on the increasing prevalence of celiac disease

Cogent Medicine

Maya G. Liester¹  Mitchell B. Liester¹ 

[1] University of Colorado School of Medicine;

关键词: gluten;    gliadin;    proline;    water stress;    epidemiology;    epigenetics;   

DOI  :  10.1080/2331205X.2018.1529848

来源: DOAJ

【 摘 要 】

Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Although the global prevalence of CD is generally estimated at 1%, this number has been found to be increasing. We propose drought contributes to the escalating prevalence of CD by increasing the proline content of gliadin peptides and altering the position of proline residues relative to glutamine residues. These changes increase the likelihood CD will develop when genetically susceptible individuals are exposed to drought-affected gluten. Additionally, selection by farmers of wheat varieties that are more tolerant to drought conditions results in an expansion of high proline gliadin peptides in our food supply. Therefore, we suggest drought directly and indirectly contributes to the increasing prevalence of CD.

【 授权许可】

Unknown