Persistent Human Papillomavirus Infection

Viruses

TamiL. Coursey¹  Simran Khurana¹  Alix Warburton¹  AshleyN.Della Fera¹  AlisonA. McBride¹ 

[1] Laboratory of Viral Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 209892, USA;

关键词: HPV;    papillomavirus;    persistence;    extrachromosomal replication;    tethering;    cancer;   

DOI  :  10.3390/v13020321

来源: DOAJ

【 摘 要 】

Persistent infection with oncogenic human papillomavirus (HPV) types is responsible for ~5% of human cancers. The HPV infectious cycle can sustain long-term infection in stratified epithelia because viral DNA is maintained as low copy number extrachromosomal plasmids in the dividing basal cells of a lesion, while progeny viral genomes are amplified to large numbers in differentiated superficial cells. The viral E1 and E2 proteins initiate viral DNA replication and maintain and partition viral genomes, in concert with the cellular replication machinery. Additionally, the E5, E6, and E7 proteins are required to evade host immune responses and to produce a cellular environment that supports viral DNA replication. An unfortunate consequence of the manipulation of cellular proliferation and differentiation is that cells become at high risk for carcinogenesis.

【 授权许可】

Unknown