Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile

Infectious Agents and Cancer

Suminori Akiba²  Alejandro Corvalán¹  Yoshito Eizuru⁴  Luisa Solís⁵  Oslando Padilla⁶  Sandra Ampuero³  Carolina González³  Chihaya Koriyama²  Noureen Khan²  Francisco Aguayo³ 

[1] Department of Hematology and Oncology, Pontificia Universidad Catolica, 85 Lira Street, Santiago 133-202, Santiago, Chile;Department of Public Health, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan;Virology Program, I.C.B.M., Faculty of Medicine, University of Chile, Independencia 1027, Santiago 838-9100, Chile;Division of Oncogenic and Persistent Viruses, Center for Chronic Viral Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan;Pathology Department, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile;Department of Public Heath, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

关键词: integration;    HPV;    cancer;    breast;    papillomavirus;   

Others  :  805487
DOI  :  10.1186/1750-9378-6-7

 received in 2011-04-21, accepted in 2011-06-23,  发布年份 2011

【 摘 要 】

Background

Human papillomavirus (HPV) and Epstein Barr virus (EBV) have been found in breast carcinomas (BCs) around the world. In this study, fifty-five BCs from Chile were analyzed for HPV and EBV presence. In addition, HPV-16 viral load/physical status and E6/E7 expressions were determined.

Results

The amplification of a housekeeping gene showed that 46/55 samples (84%) had amplifiable DNA. HPV-16 was detected in 4/46 BCs (8.7%) and EBV was detected in 3/46 (6.5%) BCs. The analysis of HPV-16 physical status showed that this virus was integrated in all of the tumors with a relatively low viral load (range: 0.14 to 33.8 copies/cell). E6 and E7 transcripts, however, were not detected in any HPV-16 positive specimens. Using a Cox-regression model, we found a statistically significant association between EBV presence and poor survival (p = 0.013).

Conclusions

The findings in this study suggest that it is unlikely that HPV and/or EBV play a direct role in the etiology of BC.

【 授权许可】

   
2011 Aguayo et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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