Immune Correlates of Natural HIV Elite Control and Simultaneous HCV Clearance—Supercontrollers

Frontiers in Immunology

Ezequiel Ruiz-Mateos¹  Jose Hernandez-Quero²  Francisco Vidal³  Sara Ferrando-Martinez⁴  Richard Koup⁴  Mª Angeles Muñoz-Fernandez⁵  Miguel Genebat⁶  Beatriz Dominguez-Molina⁶  Laura Tarancon-Diez⁶  Manuel Leal⁸ 

[1] Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital, Seville, Spain;Hospital San Cecilio, Internal Medicine, Granada, Spain;Hospital Universitari Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain;Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;Instituto de Investigación Sanitaria del Gregorio Marañón, Madrid, Spain;Laboratory of Immunovirology, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville, Seville, Spain;Sección Inmunología, Laboratory InmunoBiología Molecular, Hospital General Universitario “Gregorio Marañón”, Madrid, Spain;Servicio de Medicina Interna, Hospital Viamed, Santa Ángela de la Cruz, Seville, Spain;

关键词: HIV;    controllers;    HCV;    spontaneous clearance;    T-cells;    pDCs;   

DOI  :  10.3389/fimmu.2018.02897

来源: DOAJ

【 摘 要 】

HIV-elite controllers are a minority group of HIV-infected patients with the ability to maintain undetectable HIV viremia for long time periods without antiretroviral treatment. A small group of HIV-controllers are also able to spontaneously clear the hepatitis C virus (HCV) whom we can refer to as “supercontrollers.” There are no studies that explore immune correlates looking for the mechanisms implicated in this extraordinary phenomenon. Herein, we have analyzed HCV- and HIV-specific T-cell responses, as well as T, dendritic and NK cell phenotypes. The higher HCV-specific CD4 T-cell polyfunctionality, together with a low activation and exhaustion T-cell phenotype was found in supercontrollers. In addition, the frequency of CD8 CD161high T-cells was related with HIV- and HCV-specific T-cells polyfunctionality. Interesting features regarding NK and plasmacytoid dendritic cells (pDCs) were found. The study of the supercontroller's immune response, subjects that spontaneously controls both chronic viral infections, could provide further insights into virus-specific responses needed to develop immunotherapeutic strategies in the setting of HIV cure or HCV vaccination.

【 授权许可】

Unknown