Intralesional bleomycin for the treatment of periocular capillary hemangiomas

Indian Journal of Ophthalmology

关键词: Apoptosis;    glaucoma;    intraocular pressure;    retinal ganglion cells;    retinal ischemia;    tumor necrosis factor-alpha;    Branch retinal vein occlusion;    laser;    Lucentis;    macular edema;    Microbial etiology;    mucopurulent keratitis;    suppurative keratitis;    Intraoperative application of mitomycin C;    mitomycin C;    postoperative complications;    preoperative subconjunctival injection;    recurrence rate;    recurrent pterygium;    Cataract;    inflammation;    mydriasis;    prevention and control;    surgery;    Cross-cylinder technique;    photoastigmatic refractive keratectomy;    refractive surgery;    ′BARC I-125 Ocu-Prosta seeds′;    choroidal melanoma;    plaque brachytherapy;    retinoblastoma;    vasoproliferative tumors;    Asian Indian;    Amaurosis;    amaurosis hemianopia;    capsulolenticular cataract;    conjunctiva;    lenticular cataract;    leukoma;    eye lid;    ophthalmia chronica;    ophthalmic purulentis;    Interpretation;    magnetic resonance imaging;    orbit;    ophthalmology;    Antivascular endothelial growth factor;    intravitreal bevacizumab;    ocular inflammation;    Acute macular neuroretinopathy;    optical coherence tomography;    scotoma;    Desferrioxamine;    ocular toxicity;    optic neuropathy;    pigmentary retinopathy;    Endophthalmitis;    retinal vasculitis;    Staphylococcus epidermidis;    white-centered retinal hemorrhages;    Dextrocardia;    nanophthalmos;    situs inversus totalis;    Acquired immunodeficiency syndrome;    cerebral abscess;    human immunodeficiency virus;    homonymous hemianopsia;    initial ophthalmic manifestation;    tubercular abscess;    tuberculosis;    Chronic obstructive pulmonary disease;    globe luxation;    spontaneous;    Bleomycin;    periocular hemangiomas;    treatment;   

DOI  :  10.4103/0301-4738.98722

来源: DOAJ

【 摘 要 】

Periocular infantile capillary hemangiomas do not always respond well to conventional treatment modalities such as systemic or intralesional corticosteroids, radiotherapy or debulking surgery. The authors describe the use of intralesional bleomycin injections (IBIs) to treat potentially amblyogenic lesions in two cases where other modalities have failed. In both cases monthly IBIs successfully cleared the visual axis of the affected eye before the age of 1 year thus preventing permanent sensory deprivation amblyopia. A total of five and nine injections, respectively, were used and no significant side effects were noted. IBI appears to be a useful alternative in the treatment of periocular capillary hemangiomas refractory to more conventional modalities.

【 授权许可】

Unknown