Subtyping of high grade serous ovarian carcinoma: histopathological and immunohistochemical approach

Journal of the Egyptian National Cancer Institute

Mohamed Fawzy¹  Reham Nagib¹  Ghada Eladawei¹  Azza Abdel-Aziz¹  Marwa Khashaba² 

[1] Mansoura University;Port Said University;

关键词: Papillary serous carcinoma;    Prognosis;    Mesenchymal;    Proliferative;    Immunoreactive;   

DOI  :  10.1186/s43046-022-00104-9

来源: DOAJ

【 摘 要 】

Abstract Background High-grade serous ovarian carcinoma (HGSOC) is classified into four molecular subtypes; mesenchymal, proliferative, immunoreactive, and differentiated, with suggested different prognosis. Addressing the presence of histopathological and immunohistochemical differences in HGSOC that parallel the molecular subtypes can help in tailoring the management protocol to improve therapeutic response and patient outcome. Methods This retrospective study was conducted on 85 specimens for cases of HGSOC. Cases were classified according to histopathological findings into mesenchymal, proliferative, immunoreactive, and differentiated subtypes. Cases were immunostained with ER, PR, Ki67, CD8, E-cadherin, and vimentin. Results By applying histopathological data, cases were subdivided into 4 groups; mesenchymal type represented by 25 cases, proliferative type which included 14 cases, the immunoreactive type included 14 cases, and differentiated type represented by 32 cases; 13 of them had SET features and 19 had papillary architectural features. A significant correlation was found between Ki67 and proliferative subtype, as well as between CD8 and immunoreactive subtype. ER showed significantly higher expression in proliferative subtype in the group treated by primary debulking. CD8 showed a significant correlation with solid endometroid transitional (SET) pattern in the group that underwent interval debulking. In terms of prognosis, the shortest median progression-free survival (PFS) was for mesenchymal subtype, while the longest median PFS was for differentiated subtype with SET architectural pattern with statistically significant correlation. No correlation was found between any of the studied parameters and overall survival. Conclusion Histopathological features and immunohistochemistry can help to stratify HGSOC into prognostic distinct groups.

【 授权许可】

Unknown