Proliferative fibrocystic lesions in association with carcinoma breast- Study of mastectomy specimens

International Journal of Biomedical and Advance Research

Shashikala R ; Savithri Ravindra

关键词: s Carcinoma breast, Proliferative breast lesions, Epithelial hyperplasia, Papillomatosis, Fibrocystic lesions, Apocrine metaplasia.;   

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Background: Breast cancer remains a global health problem with an increasing incidence. Proliferative breast diseases are recognized as one of the risk factors in the development of carcinoma. The study was undertaken to know the frequency of proliferative fibrocystic lesions in association with breast carcinomas in mastectomy specimens. Material and methods: The present study included 100 cases of mastectomies for carcinoma breast at Kempegowda Institute of Medical Sciences, Bangalore from August 2010 to July 2013. The tumor and the surrounding breast tissue were studied grossly and microscopically for any co-existing neoplastic and non neoplastic lesions like epithelial hyperplasia, cystic change, apocrine metaplasia, fibrosis and adenosis. Results: The study included 100 cases of breast carcinomas. The predominant type of carcinoma (85%) was infiltrating ductal carcinoma-no specific type. Proliferative breast lesions were noted in 38 cases (38%), nonproliferative breast lesions in 27 cases (27%) and there were no changes in 35 cases (35%). Of 38 cases, proliferative lesions with atypia were noted in 20 cases and proliferative lesions without atypia were noted in 18 cases.Conclusion: Proliferative lesions in the breast carry an increased risk of developing malignancies especially when there is atypia. Women, who have been diagnosed as having proliferative breast disease, require careful follow-up, with annual mammographic screening being mandatory for women with atypical hyperplasia

【 授权许可】

CC BY