WAO-ARIA consensus on chronic cough – Part 1: Role of TRP channels in neurogenic inflammation of cough neuronal pathways

World Allergy Organization Journal

Gary W.K. Wong, MD¹  Adnan Custovic, MD, PhD²  Samar A. Idriss, MD³  Tanya M. Laidlaw, MD⁴  Mona Sulaiman AL-Ahmad, MD, FAAAI, FRCPCP⁵  Fares H. Zaitoun, MD, FACAAI⁶  Eliane Abou-Jaoude, MD⁷  R. Maximiliano Gómez, MD, PhD⁸  Anahí Yáñez, MD⁹  David Peden, MD^1,10  Giorgio Walter Canonica, MD^1,11  Maryam Ali Y. AL-Nesf, MD, MSc, R, CABHS^1,12  Mario Morais-Almeida, MD^1,13  Lianglu Wang, MD^1,14  Glenis K. Scadding, MD, FRCP^1,15  Michael Levin, MD, PhD^1,16  Jonathan A. Bernstein, MD^1,17  Georges S. Juvelekian, MD, FCCP, D'ABSM^1,18  Ludger Klimek, MD, PhD^1,19  Ignacio J. Ansotegui, MD, PhD^2,20  James Sublett, MD^2,21  Sami L. Bahna, MD, DrPH^2,22  Talal M. Nsouli, MD, FACAAI, FAAAAI^2,23  Usamah M. Hadi, MD, FACS, ERS, PARS^2,24  Jean Bousquet, MD, PhD^2,25  Philip W. Rouadi, MD^2,25  Erika Jensen-Jarolim, MD^2,26  Motohiro Ebisawa, MD, PhD^2,27  Bryan L. Martin, DO^2,28  Yoon-Seok Chang, MD, PhD^2,29  Cecilio R. Azar, MD^3,30  Luis Caraballo, MD, PhD^3,31  Peter W. Hellings, MD, PhD^3,32  Sandra N. González Díaz, MD, PhD^3,33  Peter K. Smith, BMedSci, MBBS, FRACP, PhD^3,33  Moussa A. Riachy, MD, FCCP^3,34  Luciana Kase Tanno, MD, PhD^3,35  José Antonio Ortega-Martell, MD^3,36  Manana Chikhladze, PhD^3,37  Alessandro Fiocchi, MD^3,38 

[1] Academic Medical Center, University of Amsterdam, Department of Otorhinolaryngology, Amsterdam, the Netherlands;Allergy Clinic-Humanitas Research Hospital-IRCCS-Milano Italy;Corresponding author.;Department of Audiology and Otoneurological Evaluation, Edouard Herriot Hospital, Lyon, France;Department of Dermatology and Allergy, Comprehensive Allergy Center, Berlin Institute of Health, Berlin, Germany;Department of Gastroenterology, Clemenceau Medical Center (CMC), Beirut, Lebanon;Department of Gastroenterology, Middle East Institute of Health (MEIH), Beirut, Lebanon;Immunology Section, Louisiana State University Health Sciences Center, Shreveport, LA, USA;Macvia France, Montpellier France;University Hospital Ghent, Department of Otorhinolaryngology, Laboratory of Upper Airways Research, Ghent, Belgium;University Hospitals Leuven, Department of Otorhinolaryngology, Leuven, Belgium;Université Montpellier, Montpellier, France;;Allergy &Allergy Center, CUF Descobertas Hospital, Lisboa, Portugal;Allergy and Immunology Section, Department of Medicine, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar;Center for Rhinology and Allergology, Wiesbaden, Germany;Clinical Medicine Griffith University, Southport Qld, 4215, Australia;Clinical Professor Department of Otolaryngology Head and Neck Surgery, American University of Beirut, Lebanon;Department of Allergy Otolaryngology, LAU-RIZK Medical Center, Beirut, Lebanon;;Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Department of ENT, RNENT Hospital, London, UK;Department of Gastroenterology, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon;Department of Medicine, Harvard Medical School, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital Boston, MA, USA;Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait;Department of Otolaryngology - Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon;Department of Pediatrics, Chinese University of Hong Kong, Hong Kong, China;Department of Pediatrics, Section of Allergy and Immunology, University of Louisville School of Medicine, 9800 Shelbyville Rd, Louisville, KY, USA;Department of Pulmonary and Critical Care, Hôtel-Dieu de France University Hospital, Beirut, Lebanon;Department of Pulmonary, Critical Care and Sleep Medicine at Saint George Hospital University Medical Center, Beirut, Lebanon;Hospital Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany;;Humanitas University, Personalized Medicine Asthma &INAER - Investigaciones en Alergia y Enfermedades Respiratorias, Buenos Aires, Argentina;International Cough Institute, Washington D.C, USA;KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Allergy and Clinical Immunology, Leuven, Belgium;School of Health Sciences, Catholic University of Salta, Argentina;UNC Center for Environmental Medicine, Asthma, and Lung Biology, Division of Allergy, Immunology and Rheumatology, Department of Pediatrics UNS School of Medicine, USA;Universidad Autónoma de Nuevo León, Hospital Universitario and Facultad de Medicina, Monterrey, Nuevo León, Mexico;University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Immunology/Allergy Section, Cincinnati;

关键词: TRP channel;    P2X3;    Pathogenesis;    Chronic cough;    Chemoreceptors;    Mechanoreceptors;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Cough features a complex peripheral and central neuronal network. The function of the chemosensitive and stretch (afferent) cough receptors is well described but partly understood. It is speculated that chronic cough reflects a neurogenic inflammation of the cough reflex, which becomes hypersensitive. This is mediated by neuromediators, cytokines, inflammatory cells, and a differential expression of neuronal (chemo/stretch) receptors, such as transient receptor potential (TRP) and purinergic P2X ion channels; yet the overall interaction of these mediators in neurogenic inflammation of cough pathways remains unclear. Objectives: The World Allergy Organization/Allergic Rhinitis and its Impact on Asthma (WAO/ARIA) Joint Committee on Chronic Cough reviewed the current literature on neuroanatomy and pathophysiology of chronic cough. The role of TRP ion channels in pathogenic mechanisms of the hypersensitive cough reflex was also examined. Outcomes: Chemoreceptors are better studied in cough neuronal pathways compared to stretch receptors, likely due to their anatomical overabundance in the respiratory tract, but also their distinctive functional properties. Central pathways are important in suppressive mechanisms and behavioral/affective aspects of chronic cough. Current evidence strongly suggests neurogenic inflammation induces a hypersensitive cough reflex marked by increased expression of neuromediators, mast cells, and eosinophils, among others. TRP ion channels, mainly TRP V1/A1, are important in the pathogenesis of chronic cough due to their role in mediating chemosensitivity to various endogenous and exogenous triggers, as well as a crosstalk between neurogenic and inflammatory pathways in cough-associated airways diseases.

【 授权许可】

Unknown