Modelling the Renal Excretion of the Mycotoxin Deoxynivalenol in Humans in an Everyday Situation

Toxins

Annick D. van den Brand¹  Marcel J. B. Mengelers¹  Marco Zeilmaker¹  Rudolf Hoogenveen¹  Anne Lise Brantsæter²  Trine Husøy²  Hubert A. A. M. Dirven²  Silvio Uhlig³  Gunnar S. Eriksen³ 

[1] National Institute for Public Health and the Environment (RIVM), 3721 MA Bilthoven, The Netherlands;Norwegian Institute of Public Health (NIPH), N-0213 Oslo, Norway;Norwegian Veterinary Institute (NVI), P.O. Box 64, 1431 Ås, Norway;

关键词: deoxynivalenol;    deoxynivalenol-15-glucuronide;    mycotoxin;    human biomonitoring;    dietary exposure;    renal excretion;   

DOI  :  10.3390/toxins13100675

来源: DOAJ

【 摘 要 】

The dietary exposure to the mycotoxin deoxynivalenol (DON) can be assessed by human biomonitoring (HBM). Here, we assessed the relation between dietary DON intake and the excretion of its major metabolite DON-15-glucuronide (DON15GlcA) through time, in an everyday situation. For 49 volunteers from the EuroMix biomonitoring study, the intake of DON from each meal was calculated and the excretion of DON and its metabolites was analyzed for each urine void collected separately throughout a 24-h period. The relation between DON and DON15GlcA was analyzed with a statistical model to assess the residence time and the excreted fraction of ingested DON as DON15GlcA (f_{abs_excr}). F_{abs_excr} was treated as a random effect variable to address its heterogeneity in the population. The estimated time in which 97.5% of the ingested DON was excreted as DON15GlcA was 12.1 h, the elimination half-life was 4.0 h. Based on the estimated f_{abs_excr}, the mean reversed dosimetry factor (RDF) of DON15GlcA was 2.28. This RDF can be used to calculate the amount of total DON intake in an everyday situation, based on the excreted amount of DON15GlcA. We show that urine samples collected over 24 h are the optimal design to study DON exposure by HBM.

【 授权许可】

Unknown