Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature

Frontiers in Oncology

Bo Yuan¹  Minghao Yuan²  Pei Wu³  Wenjie Peng⁴  Qian Li⁴  Lian Zhu⁴  Jiesong Zhou⁵ 

[1] Department of Nephrology, The Dazu District People’s Hospital, Chongqing, China;Department of Neurology, Chongqing Medical University, Chongqing, China;Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China;Department of Pediatrics, Army Medical Center, Army Medical University, Chongqing, China;Department of Plastic Surgery, Changhai Hospital Affiliated to Naval Medical University, Shanghai, China;

关键词: meningioma;    mechanisms;    cell proliferation;    neo-angiogenesis;    apoptosis;    immunogenicity;   

DOI  :  10.3389/fonc.2022.850463

来源: DOAJ

【 摘 要 】

Meningiomas, the most frequent primary intracranial tumors of the central nervous system in adults, originate from the meninges and meningeal spaces. Surgical resection and adjuvant radiation are considered the preferred treatment options. Although most meningiomas are benign and slow-growing, some patients suffer from tumor recurrence and disease progression, eventually resulting in poorer clinical outcomes, including malignant transformation and death. It is thus crucial to identify these “high-risk” tumors early; this requires an in-depth understanding of the molecular and genetic alterations, thereby providing a theoretical foundation for establishing personalized and precise treatment in the future. Here, we review the most up-to-date knowledge of the cellular biological alterations involved in the progression of meningiomas, including cell proliferation, neo-angiogenesis, inhibition of apoptosis, and immunogenicity. Focused genetic alterations, including chromosomal abnormalities and DNA methylation patterns, are summarized and discussed in detail. We also present latest therapeutic targets and clinical trials for meningiomas' treatment. A further understanding of cellular biological and genetic alterations will provide new prospects for the accurate screening and treatment of recurrent and progressive meningiomas.

【 授权许可】

Unknown