Protective Effects of a New Phloretin Derivative againstUVB-Induced Damage in Skin Cell Model and Human Volunteers

International Journal of Molecular Sciences

Minkyung Kim¹  Seoungwoo Shin¹  Hyunwoo Kum¹  Deokhoon Park¹  Dehun Ryu¹  Eunsun Jung¹ 

[1] Biospectrum Life Science Institute, Seoungnam City, Gyunggi Do 462-807, Korea;

关键词: phloretin 3',3-disulfonate;    photoprotection;    anti-inflammation;    sulfonation;   

DOI  :  10.3390/ijms151018919

来源: DOAJ

【 摘 要 】

The phenolic compound phloretin is a prominent member of the chemical class of dihydrochalcones. Phloretin is specifically found in apple and apple juice and knownfor its biological properties. We were particularly interested in its potential dermo-cosmetic applications. However, practical limitations of phloretin do exist due to its poorwater-solubility. Phloretin was sulfonated with sulfuric acid (98%, wt) and mixedwith saturated salt water to produce phloretin 3',3-disulfonate in order to increase itswater-solubility. Here we reported the photoprotective effect of phloretin 3',3-disulfonate (PS), a new semi-synthetic derivative of phloretin. Results showed that PS attenuated cyclobutane pyrimidine dimer (CPDs) formation, glutathione (GSH) depletion and apoptosis induced by ultraviolet B (UVB). The photoprotective effect of PS is tightly correlated to the enhancement of nucleotide excision repair (NER) gene expression. Furthemore, PS had inhibitory effects on UVB-induced release of the inflammatory mediators, such as IL-6 and prostaglandin-E2. We also confirmed the safety and clinical efficacy of PS on human skin. Overall, the results demonstrated significant benefits of PS on the protection of keratinocytes against UVB-induced injuries and suggested its potential use in skin photoprotection.

【 授权许可】

Unknown