Hepatoprotective Effects of Extract of Helicteres hirsuta Lour. on Liver Fibrosis Induced by Carbon Tetrachloride in Rats

Applied Sciences

Le Tuan Anh Hoang¹  Ngo Viet Duc¹  Dac Thang Hoang²  Thi Thu Hien Truong²  Gao Dan³  Seo Young Yang⁴  Thi Thao Do⁵  Le Ba Vinh⁶  Le Tuan Anh⁷ 

[1] Center for Research and Technology Transfer, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Hanoi 100000, Vietnam;Centre for Toxicology and Radiology Teaching and Research, Vietnam Military Medical University, 160 Phung Hung, Ha Dong, Hanoi 100000, Vietnam;College of Pharmacy, Chungnam National University, Daejeon 34134, Korea;Department of Pharmaceutical Engineering, Sangji University, Wonju 26339, Korea;Institute of Biotechnology, VAST, Hanoi 100000, Vietnam;Institute of Marine Biochemistry, VAST, Hanoi 100000, Vietnam;MienTrung Institute for Scientific Research, VAST, 321 Huynh Thuc Khang, Hue City 52000, Vietnam;

关键词: Helicteres hirsuta;    hepatoprotective activity;    cirrhosis;    carbon tetrachloride;    acute toxicity;   

DOI  :  10.3390/app11188758

来源: DOAJ

【 摘 要 】

Helicteres hirsuta Lour. is a traditional Vietnamese medicine for treating chronic liver diseases such as cirrhosis and liver cancer. Many in vitro and in vivo experiments have demonstrated that the extracts and isolated compounds from H. hirsuta have diverse pharmacological activities, including antioxidant, anti-inflammatory, and anti-cancer effects. However, the hepatoprotective effects have not been reported until now. Therefore, the methanolic and ethanolic extracts of the aerial part of the H. hirsuta L. (HHM and HHE-1/1) were examined on liver fibrosis induced by carbon tetrachloride (CCl₄) in rats for the first time. The results revealed that all the livers of the model group had stage F4 cirrhosis; the group that received silymarin, and HHM and HHE-1/1 had milder liver damage cirrhosis stage F1-F2 which implies that the methanolic and ethanolic extracts of H. hirsute have a definite advantage in the development of food or oral medications for hepatoprotective activity.

【 授权许可】

Unknown