Complete Genome Sequences of Klebsiella michiganensis and Citrobacter farmeri, KPC-2-Producers Serially Isolated from a Single Patient

Antibiotics

Paul H. Roy¹  Jehane Y. Abed¹  Maurice Boissinot¹  Jacques Corbeil¹  Ève Bérubé¹  Maxime Déraspe¹  Michel G. Bergeron¹  Ken Dewar²  Matthew D’Iorio³ 

[1] Centre de Recherche en Infectiologie, Centre de Recherche du CHU de Québec, Université Laval, 2705 boul. Laurier, Suite R-0709, Québec, QC G1V 4G2, Canada;Department of Human Genetics, McGill University, 3640 rue University, Rm 2/38F, Montréal, QC H3A 0C7, Canada;McGill Genome Centre, 740 Avenue Docteur-Penfield, Montréal, QC H3A 0G1, Canada;

关键词: Klebsiella michiganensis;    Citrobacter farmeri;    KPC-2;    carbapenemase;    plasmid;    transposon;   

DOI  :  10.3390/antibiotics10111408

来源: DOAJ

【 摘 要 】

Carbapenemase-producing Enterobacterales, including KPC-2 producers, have become a major clinical problem. During an outbreak in Quebec City, Canada, KPC-2-producing Klebsiella michiganensis and Citrobacter farmeri were isolated from a patient six weeks apart. We determined their complete genome sequences. Both isolates carried nearly identical IncN2 plasmids with blaKPC-2 on a Tn4401b element. Both strains also carried IncP1 plasmids, but that of C. farmeri did not carry a Beta-lactamase gene, whereas that of K. michiganensis carried a second copy of bla_KPC-2 on Tn4401b. These results suggest recent plasmid transfer between the two species and a recent transposition event.

【 授权许可】

Unknown