Carbapenemase-producing Enterobacteriaceae in Mexico: report of seven non-clonal cases in a pediatric hospital

BMC Microbiology

Eduardo Arias de la Garza¹  Alejandra Aquino-Andrade²  Jocelin Merida-Vieyra³ 

[1] Clinical Bacteriology Laboratory, Instituto Nacional de Pediatria, Mexico City, Mexico;Molecular Microbiology Laboratory, Instituto Nacional de Pediatra, Coyoacn Mexico City, Mexico;Pediatric Infectious Disease Department, Instituto Nacional de Pediatria, Mexico City, Mexico

关键词: Carbapenemase-producing Enterobacteriaceae;    Pediatrics;    Mexico;    NDM-1;    KPC-2;    OXA-48;    OXA-232;   

DOI  :  10.1186/s12866-018-1166-z

学科分类：微生物学和免疫学

来源: BioMed Central

【 摘 要 】

Carbapenemases-producing Enterobacteriaceae (CPE) are a worldwide public health emergency. In Mexico, reports of CPE are limited, particularly in the pediatric population. Here, we describe the clinical, epidemiological, and molecular characteristics of seven consecutive cases in a third-level pediatric hospital in Mexico City over a four-month period during 2016. The Enterobacteriaceae identified were three Escherichia coli strains (producing OXA-232, NDM-1 and KPC-2), two Klebsiella pneumoniae strains (producing KPC-2 and NDM-1), one Klebsiella oxytoca strain producing OXA-48 and one Enterobacter cloacae strain producing NDM-1. The majority of patients had underlying disesases, three were immunocompromised, and three had infections involved the skin and soft tissues. Half patients died as a result of CPE infection. This study represents the first report of E. coli ST131-O25b clone producing NDM-1 in Latin America. In addition, this study is the first finding of K. oxytoca producing OXA-48 and E. coli producing OXA-232 in Mexican pediatric patients.

【 授权许可】

CC BY