Gastrointestinal Mechanisms Underlying the Cardiovascular Effect of Metformin

Pharmaceuticals

MalcolmJ. Borg¹  Michael Horowitz¹  KarenL. Jones¹  Tongzhi Wu¹  Cong Xie¹  ChristopherK. Rayner¹ 

[1] Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide 5000, Australia;

关键词: metformin;    cardiovascular;    gastrointestinal;    mechanisms;    bile acids;    gut microbiota;   

DOI  :  10.3390/ph13110410

来源: DOAJ

【 摘 要 】

Metformin, the most widely prescribed drug therapy for type 2 diabetes, has pleiotropic benefits, in addition to its capacity to lower elevated blood glucose levels, including mitigation of cardiovascular risk. The mechanisms underlying the latter remain unclear. Mechanistic studies have, hitherto, focused on the direct effects of metformin on the heart and vasculature. It is now appreciated that effects in the gastrointestinal tract are important to glucose-lowering by metformin. Gastrointestinal actions of metformin also have major implications for cardiovascular function. This review summarizes the gastrointestinal mechanisms underlying the action of metformin and their potential relevance to cardiovascular benefits.

【 授权许可】

Unknown