Differential Impacts of Alternative Splicing Networks on Apoptosis

International Journal of Molecular Sciences

Mei-Fen Tsao¹  Ying-Ju Lin²  Jung-Chun Lin³ 

[1] Department of Laboratory Medicine, Taipei Medical University Hospital, Taipei 11031, Taiwan;School of Chinese Medicine, China Medical University, Taichung 404, Taiwan;School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan;

关键词: alternative splicing;    apoptosis;    organogenesis;    carcinogenesis;   

DOI  :  10.3390/ijms17122097

来源: DOAJ

【 摘 要 】

Apoptosis functions as a common mechanism to eliminate unnecessary or damaged cells during cell renewal and tissue development in multicellular organisms. More than 200 proteins constitute complex networks involved in apoptotic regulation. Imbalanced expressions of apoptosis-related factors frequently lead to malignant diseases. The biological functions of several apoptotic factors are manipulated through alternative splicing mechanisms which expand gene diversity by generating discrete variants from one messenger RNA precursor. It is widely observed that alternatively-spliced variants encoded from apoptosis-related genes exhibit differential effects on apoptotic regulation. Alternative splicing events are meticulously regulated by the interplay between trans-splicing factors and cis-responsive elements surrounding the regulated exons. The major focus of this review is to highlight recent studies that illustrate the influences of alternative splicing networks on apoptotic regulation which participates in diverse cellular processes and diseases.

【 授权许可】

Unknown