Beneficial and deleterious bacterial–host interactions in chronic wound pathophysiology

Chronic Wound Care Management and Research

关键词: Chronic wounds;    biofilms;    wound pH;    Pseudomonas aeruginosa;    Staphylococcus aureus;    probiotics;   

DOI  :  

来源: DOAJ

【 摘 要 】

Chase Watters,1 Tony T Yuan,1,2 Kendra P Rumbaugh31Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA; 2Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, TX, USA; 3Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX, USAAbstract: Chronic wounds represent a major health and financial burden. Although incredible advancements in wound management have been made in the last decade, the incidences of chronic wounds continue to increase due to a rise in biofilm-associated infections. The presence of biofilm causes chronic inflammation, leading to impaired healing rates and host mortality. This review describes the deleterious bacterial–host interactions, as well as the beneficial role of pH and probiotics in chronic wound infections.Keywords: chronic wounds, biofilms, wound pH, Pseudomonas aeruginosa, Staphylococcus aureus, probiotics

【 授权许可】

Unknown