How Elongator Acetylates tRNA Bases

International Journal of Molecular Sciences

Nour-el-Hana Abbassi¹  Sebastian Glatt¹  Ting-Yu Lin¹  Anna Biela¹ 

[1] Malopolska Centre of Biotechnology, Jagiellonian University, 30-387 Kraków, Poland;

关键词: Elongator;    Elp3;    tRNA modification;    acetyl-CoA;    proteome balance;    cancers;   

DOI  :  10.3390/ijms21218209

来源: DOAJ

【 摘 要 】

Elp3, the catalytic subunit of the eukaryotic Elongator complex, is a lysine acetyltransferase that acetylates the C5 position of wobble-base uridines (U₃₄) in transfer RNAs (tRNAs). This Elongator-dependent RNA acetylation of anticodon bases affects the ribosomal translation elongation rates and directly links acetyl-CoA metabolism to both protein synthesis rates and the proteome integrity. Of note, several human diseases, including various cancers and neurodegenerative disorders, correlate with the dysregulation of Elongator’s tRNA modification activity. In this review, we focus on recent findings regarding the structure of Elp3 and the role of acetyl-CoA during its unique modification reaction.

【 授权许可】

Unknown