Probiotic Gastrointestinal Transit and Colonization After Oral Administration: A Long Journey

Frontiers in Cellular and Infection Microbiology

Jie Liu¹  Zongxin Ling¹  Longxian Lv²  Ziyuan Wang²  Lanjuan Li³  Yanmeng Lu⁴  Yiqiu Fei⁴  Jiaojiao Xie⁴  Guiwen Zheng⁴  Shengyi Han⁴  Björn Berglund⁴  Mingfei Yao⁴ 

[1] Business University (BTBU), Beijing, China;;China-Canada Joint Lab of Food Nutrition and Health (Beijing), Beijing Technology &Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden;State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;

关键词: probiotics;    colonization;    adhesion;    colonization resistance;    gut microbiota;   

DOI  :  10.3389/fcimb.2021.609722

来源: DOAJ

【 摘 要 】

Orally administered probiotics encounter various challenges on their journey through the mouth, stomach, intestine and colon. The health benefits of probiotics are diminished mainly due to the substantial reduction of viable probiotic bacteria under the harsh conditions in the gastrointestinal tract and the colonization resistance caused by commensal bacteria. In this review, we illustrate the factors affecting probiotic viability and their mucoadhesive properties through their journey in the gastrointestinal tract, including a discussion on various mucosadhesion-related proteins on the probiotic cell surface which facilitate colonization.

【 授权许可】

Unknown