Probiotic Gastrointestinal Transit and Colonization After Oral Administration: A Long Journey

Frontiers in Cellular and Infection Microbiology

Ziyuan Wang¹  Jie Liu¹  Shengyi Han²  Zongxin Ling²  Mingfei Yao²  Lanjuan Li²  Longxian Lv²  Guiwen Zheng²  Yanmeng Lu²  Yiqiu Fei²  Jiaojiao Xie²  Björn Berglund³ 

[1] China-Canada Joint Lab of Food Nutrition and Health (Beijing), Beijing Technology & Business University (BTBU), Beijing, China;State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden;

关键词: probiotics;    colonization;    adhesion;    colonization resistance;    gut microbiota;   

DOI  :  10.3389/fcimb.2021.609722

来源: Frontiers

【 摘 要 】

Orally administered probiotics encounter various challenges on their journey through the mouth, stomach, intestine and colon. The health benefits of probiotics are diminished mainly due to the substantial reduction of viable probiotic bacteria under the harsh conditions in the gastrointestinal tract and the colonization resistance caused by commensal bacteria. In this review, we illustrate the factors affecting probiotic viability and their mucoadhesive properties through their journey in the gastrointestinal tract, including a discussion on various mucosadhesion-related proteins on the probiotic cell surface which facilitate colonization.

【 授权许可】

CC BY