Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF-κB Signaling Pathway

Kidney & Blood Pressure Research

关键词: Inflammatory;    Glomerulonephritis;    Signaling pathway;    Triptolide;   

DOI  :  10.1159/000452591

来源: DOAJ

【 摘 要 】

Background/Aims: Triptolide (TPL), a main active ingredient of Tripterygium wilfordii has been shown to exert anti-inflammatory effect. The role of TPL on glomerular diseases remains unclear. Methods: This study aims to investigate the potential anti-inflammatory effect of TPL in rats with membranous glomerulonephritis (MGN). Results: Our data showed that the pathological kidney damage was significantly alleviated by TPL treatment in MGN rats. We also found that MGN rats exhibited significantly higher (p Conclusion: Together, all above results suggest that inflammatory response could be attenuated by TPL and this is partly due to the inhibition of NF- κB signaling pathway.

【 授权许可】

Unknown