Triptolide exhibits anti-inflammatory, anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1β treated human intervertebral disc cells

European Spine Journal

K. Wuertz¹  T. Liebscher¹  J. Klasen¹  M. Klawitter¹  N. Boos¹  A. Nerlich¹  L. Quero¹ 

[1] Spine Research Group, Competence Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Winterthurerstrasse 190 (17L28), 8057 Zurich, Switzerland

关键词: Intervertebral disc;    Triptolide;    Gene expression;    Immunoblotting;    Signaling pathway;   

DOI  :  10.1007/s00586-011-1919-y

学科分类：骨科学

来源: Springer

【 摘 要 】

Increased levels of proinflammatory cytokines seem to play a pivotal role in the development of back pain in a subpopulation of patients with degenerative intervertebral disc (IVD) disease. As current treatment options are mostly limited to surgical interventions or conservative treatment, anti-inflammatory substances might offer a novel, more target-orientated therapeutic approach. Triptolide (TPL), a natural substance found in the Chinese medicinal herb Tripterygium wilfordii Hook, has been demonstrated to possess anti-inflammatory effects in various cells, but no studies exist so far for the IVD. Therefore, the aim of this study was to determine the effects of TPL on human IVD cells by analyzing changes in gene expression and underlying molecular mechanisms.

【 授权许可】

Unknown