Effects of Paternal Obesity on Fetal Development and Pregnancy Complications: A Prospective Clinical Cohort Study

Frontiers in Endocrinology

Hefeng Huang²  Wei Gu³  Jing Lin³ 

[1] International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China;Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;

关键词: paternal obesity;    macrosomia;    SGA;    preeclampsia;    cohort study;   

DOI  :  10.3389/fendo.2022.826665

来源: DOAJ

【 摘 要 】

ObjectivesTo evaluate the association between paternal obesity and fetal development and pregnancy complications.Study DesignThis prospective cohort clinical trial analyzed data from 7683 women with singleton pregnancies. All study subjects were sequentially divided into four groups based on paternal BMI. We compared the differences in fetal growth and pregnancy complications between different paternal BMI groups by univariate logistic regression and independent t-test. Finally, the independent predictors of SGA and macrosomia were determined.ResultsThe incidences of preeclampsia, cesarean section, SGA, macrosomia, and postpartum hemorrhage in the paternal obesity group were significantly higher than the normal BMI group. With the increase of paternal BMI, fetal ultrasound measurement parameter, neonatal and placental weight showed an increasing trend (trend P < 0.05). However, these differences disappeared in the obese group. The test for interaction showed the effect of paternal obesity on SGA and macrosomia was significantly affected by maternal obesity. We also found paternal obesity was an independent predictor of both SGA and macrosomia. Based on the above results, we plotted the Nomograms for clinical prediction.ConclusionPaternal obesity can affect fetal growth parameters and placental development, which has an adverse impact on pregnancy outcomes. Optimizing the paternal BMI will help improve the health of the next generation.

【 授权许可】

Unknown