Prepregnancy obesity and the risk of gestational diabetes mellitus

BMC Pregnancy and Childbirth

Research Article

Anussara Kongubol¹  Vorapong Phupong¹ 

[1] Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Rama IV Road, 10330, Pathumwan, Bangkok, Thailand;

关键词: prepregnancy;    obesity;    gestational diabetes mellitus;    preeclampsia;    macrosomia;   

DOI  :  10.1186/1471-2393-11-59

 received in 2011-04-12, accepted in 2011-08-10,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundPrepregnancy obesity is associated with increased risk for adverse pregnancy outcome such as gestational diabetes mellitus (GDM), gestational hypertension, preeclampsia, fetal macrosomia and the need for cesarean delivery. The objectives of this study assessed whether Thai women classified as obese according to WHO's recommended body mass index (BMI) for Asians were at risk for developing gestational diabetes mellitus (GDM) and other complications such as preeclampsia, gestational hypertension and fetal macrosomia.MethodsTwo hundred and forty women participated in this study and followed prospectively until delivery. Half of the women (n = 120) were obese (BMI ≥ 27.5 kg/m2) and the other half (n = 120) had normal weight (BMI > 18.5-23 kg/m2). Maternal demographic data, obstetric and neonatal outcomes from both groups were compared to each other. Relative risk and 95% confidence interval (CI) were calculated.ResultsCompared to normal weight women, obese Thai women were not at increased risk for gestational diabetes mellitus (RR = 0.9 [95% CI 0.6-1.4]). Relative risk of preeclampsia and fetal macrosomia in obese women were 0.7 [95% CI 0.2-3.3] and 1.4 [95% CI 0.5-4.3], respectively. Relative risk of gestational hypertension in obese women was 12 [95% CI 1.6-90.8].ConclusionWhen WHO's classification of obesity was used for Asian populations, prepregnancy obesity without metabolic problems did not increase the risk for GDM, preeclampsia and fetal macrosomia in Thai women. But, prepregnancy obesity continued to increase the risk for developing gestational hypertension.

【 授权许可】

CC BY   
© Kongubol and Phupong; licensee BioMed Central Ltd. 2011