Opuntia ficus-indica Alleviates Particulate Matter 10 Plus Diesel Exhaust Particles (PM10D)—Induced Airway Inflammation by Suppressing the Expression of Inflammatory Cytokines and Chemokines

Plants

Young-Sil Lee¹  Geung-Joo Lee²  Yang-Chun Park³  In-Jae Park⁴  Bong-Kyun Kim⁴  Seung-Hyung Kim⁵  Won-Kyung Yang⁵  Ye-Rin Park⁵  Hyung-Sik Kang⁶ 

[1] AtoGen Co., Ltd., Daejeon 34015, Korea;Department of Horticulture, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea;Division of Respiratory Medicine, Department of Internal Medicine, College of Korean Medicine, Daejeon University, Daejeon 34520, Korea;Hurum Co., Ltd. Room 416, Daeryung Techno-Town III, 115, Gasan Digital 2-ro, Geumcheon-gu, Seoul 08505, Korea;Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon 34520, Korea;School of Biological Sciences and Technology, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea;

关键词: airway inflammation;    Opuntia ficus-indica;    particulate matter;    diesel exhaust particle;    PM10D-induced respiratory disease;   

DOI  :  10.3390/plants11040520

来源: DOAJ

【 摘 要 】

Particulate matter (PM) exposure may cause adverse health effects such as respiratory disorders. We evaluated the protective effects of various Opuntia ficus-indica (OFI) extracts on airway inflammation associated with exposure to PM10D with an aerodynamic diameter <10 μm (PM10) and diesel exhaust particles (DEP). BALB/c mice were exposed to PM10D via intranasal tracheal injection three times over a period of 12 days and various OFI extracts (water, 30% ethanolic, or 50% ethanolic extracts) were administered orally for 12 days. All OFI extracts suppressed neutrophil infiltration and the number of immune cells (CD3⁺/CD4⁺, CD3⁺/CD8⁺, and Gr-1⁺/CD11b) in bronchoalveolar lavage fluid (BALF) and lungs. OFI extracts decreased the expression of cytokines and chemokines, including chemokine (C-X-C motif) ligand (CXCL)-1, interleukin (IL)-17, macrophage inflammatory protein-2, tumor necrosis factor (TNF)-α, cyclooxygenase-2, IL-1α, IL-1β, IL-5, IL-6, transient receptor potential cation channel subfamily V member 1, and mucin 5AC, and inhibited IRAK-1, TNF-α, and CXCL-1 localization in BALF and lungs of mice with PM10D-induced airway inflammation. Serum asymmetric and symmetric dimethyl arginine levels were also decreased by OFI extracts treatment. Moreover, all OFI extracts restored histopathological damage in the trachea and lungs of mice with PM10D-induced airway inflammation. These results indicate that OFI extracts may be used to prevent and treat airway inflammation and respiratory diseases.

【 授权许可】

Unknown