Short-term exposure to stone minerals used in asphalt affect lung function and promote pulmonary inflammation among healthy adults

Scandinavian Journal of Work, Environment & Health

Johan Øvrevik¹  Bjørn Hilt¹  Hans Jørgen Dahlman¹  Magne Refsnes¹  Kristin V Hirsch Svendsen¹  Marit Låg¹  Rikke Bramming Jørgensen¹  Kirsti Sørås¹  Therese Nitter Moazami² 

[1] ;Department of Industrial Economics and Technology Management (IØT), Norwegian University of Science and Technology (NTNU), Alfred Getz veg 3, 7491 Trondheim, Norway.;

关键词: exposure;    lung function;    pulmonary inflammation;    asphalt;    airway inflammation;    particulate matter;    stone mineral;    urban air pollution;    human exposure chamber;    non-exhaust emission;    rhomb porphyry;    quartz diorite;   

DOI  :  10.5271/sjweh.4023

来源: DOAJ

【 摘 要 】

OBJECTIVE: Stone minerals are a partially ignored environmental challenge but a significant contributor to urban air pollution. We examined if short-term exposure to two stone minerals – quartz diorite and rhomb porphyry – commonly used in asphalt pavement would affect lung function, promote pulmonary inflammation, and affect bronchial reactivity differently. METHODS: Our randomized crossover study included 24 healthy, non-smoking young adults exposed to the stone minerals quartz diorite, rhomb porphyry, and control dust (lactose). Exposure occurred in an exposure chamber, in three separate 4-hour exposure sessions. Fractional exhaled nitric oxide (FeNO) and lung function were monitored before exposure, then immediately following exposure, and 4 and 24 hours after exposure. In addition, methacholine was administered 4 hours following exposure, and exhaled breath condensate (EBC) was collected before exposure, then immediately and 4 hours after exposure. EBC was analyzed for pH, thiobarbituric acid reactive substances (TBARS), intercellular adhesion molecule 1 (ICAM-1), interleukin-6 (IL-6), IL-10, P-Selectin, surfactant protein D (SP-D), and tumor necrosis factor-α (TNF-α). RESULTS: Our results showed significantly elevated concentrations of FeNO after exposure to quartz diorite compared to rhomb porphyry, suggesting that quartz diorite is more likely to trigger pulmonary inflammation after short-term exposure. Moreover, short-term exposure to rhomb porphyry was associated with a modest but statistically significant decline in forced vital capacity (FVC) compared to quartz diorite. CONCLUSION: These results emphasize that using stone material in asphalt road construction should be reconsidered as it may affect lung inflammation and lung function in exposed subjects.

【 授权许可】

Unknown