Combined Application of Quantitative Susceptibility Mapping and Diffusion Kurtosis Imaging Techniques to Investigate the Effect of Iron Deposition on Microstructural Changes in the Brain in Parkinson’s Disease

Frontiers in Aging Neuroscience

Yinghua Xuan¹  Jianping Niu²  Zerui Zhuang³  Yongyan Sun⁴  Gen Yan⁵  Yanlong Jia⁶  Lin Yang⁶  Jitian Guan⁶  Yan Cheng⁶  Yunjie Rong⁷  Renhua Wu⁸ 

[1] Department of Basic Medicine, Xiamen Medical College, Xiamen, China;Department of Neurology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China;Department of Neurosurgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China;Department of Pharmacy, Guangdong Second Provincial General Hospital, Zhuhai Hospital, Zhuhai, China;Department of Radiology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China;Department of Radiology, The Second Affiliated Hospital, Medical College of Shantou University, Shantou, China;Department of Ultrasound, Foshan Women and Children’s Hospital Affiliated to Southern Medical University, Foshan, China;Guangdong Provincial Key Laboratory for Breast Cancer Diagnosis and Treatment, Cancer Hospital of Shantou University Medical College, Shantou, China;

关键词: Parkinson’s disease (PD);    quantitative susceptibility mapping (QSM);    diffusion kurtosis imaging (DKI);    iron content;    microstructure;   

DOI  :  10.3389/fnagi.2022.792778

来源: DOAJ

【 摘 要 】

ObjectivesBrain iron deposition and microstructural changes in brain tissue are associated with Parkinson’s disease (PD). However, the correlation between these factors in Parkinson’s disease has been little studied. This study aimed to use quantitative susceptibility mapping combined with diffusion kurtosis imaging to investigate the effects of iron deposition on microstructural tissue alterations in the brain.MethodsQuantitative susceptibility mapping and diffusion kurtosis imaging were performed on 24 patients with early PD, 13 patients with advanced PD, and 25 healthy controls. The mean values of magnetic susceptibility and diffusion kurtosis were calculated for the bilateral substantia nigra, red nucleus, putamen, globus pallidus, and caudate nucleus, and compared between the groups. Correlation analyses between the diffusion kurtosis of each nucleus and its magnetic susceptibility parameters in PD patients and healthy controls were performed.ResultsThe study found a significant increase in iron deposition in the substantia nigra, red nucleus, putamen and globus pallidus, bilaterally, in patients with PD. Mean kurtosis values were increased in the substantia nigra but decreased in the globus pallidus; axial kurtosis values were decreased in both the substantia nigra and red nucleus; radial kurtosis values were increased in the substantia nigra but showed an opposite trend in the globus pallidus and caudate nucleus. In the substantia nigra of patients with PD, magnetic susceptibility was positively correlated with mean and radial kurtosis values, and negatively correlated with axial kurtosis. None of these correlations were significantly different in the control group. In the putamen, magnetic susceptibility was positively correlated with mean, axial, and radial kurtosis only in patients with advanced-stage PD.ConclusionOur study provides new evidence for brain iron content and microstructural alterations in patients with PD. Iron deposition may be a common mechanism for microstructural alterations in the substantia nigra and putamen of patients with PD. Tracking the dynamic changes in iron content and microstructure throughout the course of PD will help us to better understand the dynamics of iron metabolism and microstructural alterations in the pathogenesis of PD and to develop new approaches to monitor and treat PD.

【 授权许可】

Unknown