Chatting with the neighbors: Crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders

Frontiers in Neuroscience

Peter eClaus¹  Sebastian eRademacher¹  Niko eHensel² 

[1]Center for Systems Neuroscience (ZSN) Hannover

[2]Hannover Medical School

关键词: Actomyosin;    Alzheimer Disease;    Huntington Disease;    Microglia;    Multiple Sclerosis;    Parkinson Disease;   

DOI  :  10.3389/fnins.2015.00198

来源: DOAJ

【 摘 要 】

ROCK inhibition has been largely applied as a strategy to treat neurodegenerative diseases (NDDs) and promising results have been obtained in the recent years. However, the underlying molecular and cellular mechanisms are not fully understood and different models have been proposed for neurodegenerative disorders. Here, we aim to review the current knowledge obtained for NDDs identifying common mechanisms as well as disease-specific models. In addition to the role of ROCK in different cell types such as neurons and microglia, we focus on the molecular signaling-pathways which mediate the beneficial effects of ROCK. Besides canonical ROCK signaling, modulation of neighboring pathways by non-canonical ROCK-crosstalks is a recurrent pattern in many NDD-model systems and has been suggested to mediate beneficial effects of ROCK-inhibition.

【 授权许可】

Unknown