PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression—A Randomized Controlled Trial

Nutrients

ThomazF. S. Bastiaanssen¹  Jolana Wagner-Skacel²  Walter Wurm³  ValerieS. Falzberger³  Martina Platzer³  Robert Queissner³  Annamaria Painold³  FrederikeT. Fellendorf³  Melanie Lenger³  Helmut Schöggl³  Renate Unterweger³  Alexandra Rieger³  Werner Fitz³  Armin Birner³  Sabrina Mörkl³  Nina Dalkner³  SusanneA. Bengesser³  Karin Schwalsberger³  EvaZ. Reininghaus³  Birgitta Leitner-Afschar³  Alexander Maget³  Alexandra Kohlhammer-Dohr³  Theressa Lahousen-Luxenberger³  Carlo Hamm³  Daniela Amberger-Otti³  Martina Brunnmayr⁴  Bernd Reininghaus⁴ 

[1] Department of Anatomy and Neuroscience, University College Cork, T12 YN60 Cork, Ireland;Department of Medical Psychology and Psychosomatics, Medical University of Graz, 8036 Graz, Austria;Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, Austria;TZ-Justus Park, 4540 Bad Hall, Austria;

关键词: depression;    affective disorders;    gut-brain-axis;    probiotics;    inflammation;    microbiome;   

DOI  :  10.3390/nu12113422

来源: DOAJ

【 摘 要 】

Gut microbiota are suspected to affect brain functions and behavior as well as lowering inflammation status. Therefore, an effect on depression has already been suggested by recent research. The aim of this randomized double-blind controlled trial was to evaluate the effect of probiotic treatment in depressed individuals. Within inpatient care, 82 currently depressed individuals were randomly assigned to either receive a multistrain probiotic plus biotin treatment or biotin plus placebo for 28 days. Clinical symptoms as well as gut microbiome were analyzed at the begin of the study, after one and after four weeks. After 16S rRNA analysis, microbiome samples were bioinformatically explored using QIIME, SPSS, R and Piphillin. Both groups improved significantly regarding psychiatric symptoms. Ruminococcus gauvreauii and Coprococcus 3 were more abundant and β-diversity was higher in the probiotics group after 28 days. KEGG-analysis showed elevated inflammation-regulatory and metabolic pathways in the intervention group. The elevated abundance of potentially beneficial bacteria after probiotic treatment allows speculations on the functionality of probiotic treatment in depressed individuals. Furthermore, the finding of upregulated vitamin B6 and B7 synthesis underlines the connection between the quality of diet, gut microbiota and mental health through the regulation of metabolic functions, anti-inflammatory and anti-apoptotic properties. Concluding, four-week probiotic plus biotin supplementation, in inpatient individuals with a major depressive disorder diagnosis, showed an overall beneficial effect of clinical treatment. However, probiotic intervention compared to placebo only differed in microbial diversity profile, not in clinical outcome measures.

【 授权许可】

Unknown