Interleukin-6 Gene Expression Changes after a 4-Week Intake of a Multispecies Probiotic in Major Depressive Disorder—Preliminary Results of the PROVIT Study

Nutrients

Anne-Christin Hauschild¹  Martina Platzer²  Robert Queissner²  Jolana Wagner-Skacel²  Lilli-Marie Mendel²  FrederikeT. Fellendorf²  Melanie Lenger²  Helmut Schöggl²  Matthias Seidl²  Renate Unterweger²  Kathrin Kreuzer²  Armin Birner²  Sabrina Mörkl²  Alexandra Reiter²  Nina Dalkner²  Rene Pilz²  SusanneA. Bengesser²  Birgitta Leitner-Afschar²  Alexander Maget²  Eva Reininghaus²  Alexandra Kohlhammer-Dohr²  Hans-Peter Kapfhammer²  Carlo Hamm²  Theresa Lahousen²  Daniela Amberger-Otti²  Anna-Maria Birkl-Töglhofer³  Johannes Haybäck³  Tanja Färber⁴ 

[1] Department of Mathematics & Computer Science, University of Marburg, 35043 Marburg, Germany;Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Auenbruggerplatz 31, 8036 Graz, Austria;Institute for Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, 6020 Innsbruck, Austria;Institute of Psychology, University of Bamberg, 96047 Bamberg, Germany;

关键词: depression;    gut-brain-axis;    probiotics;    gene expression;    interleukin-6;   

DOI  :  10.3390/nu12092575

来源: DOAJ

【 摘 要 】

Major depressive disorder (MDD) is a prevalent disease, in which one third of sufferers do not respond to antidepressants. Probiotics have the potential to be well-tolerated and cost-efficient treatment options. However, the molecular pathways of their effects are not fully elucidated yet. Based on previous literature, we assume that probiotics can positively influence inflammatory mechanisms. We aimed at analyzing the effects of probiotics on gene expression of inflammation genes as part of the randomized, placebo-controlled, multispecies probiotics PROVIT study in Graz, Austria. Fasting blood of 61 inpatients with MDD was collected before and after four weeks of probiotic intake or placebo. We analyzed the effects on gene expression of tumor necrosis factor (TNF), nuclear factor kappa B subunit 1 (NFKB1) and interleukin-6 (IL-6). In IL-6 we found no significant main effects for group (F_(1,44) = 1.33, p = ns) nor time (F_(1,44) = 0.00, p = ns), but interaction was significant (F_(1,44) = 5.67, p < 0.05). The intervention group showed decreasing IL-6 gene expression levels while the placebo group showed increasing gene expression levels of IL-6. Probiotics could be a useful additional treatment in MDD, due to their anti-inflammatory effects. Results of the current study are promising, but further studies are required to investigate the beneficial effects of probiotic interventions in depressed individuals.

【 授权许可】

Unknown