Adenosine Triphosphate Release and P2 Receptor Signaling in Piezo1 Channel-Dependent Mechanoregulation

Frontiers in Pharmacology

Xuebin Yang¹  Dongliang Li²  Sébastien Roger³  Lin-Hua Jiang³  Jing Li⁴  Fatema Mousawi⁵  Linyu Wei⁶ 

[1] Department of Oral Biology, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom;Department of Physiology, Sanquan College of Xinxiang Medical University, Xinxiang, China;EA4245, Transplantation, Immunology and Inflammation, Faculty of Medicine, University of Tours, Tours, France;Lingnan Medical Research Centre, School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China;School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom;Sino-UK Joint Laboratory of Brain Function and Injury and Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, China;

关键词: mechanical stimuli;    mechanosensitive cells;    Piezo1 channel;    adenosine triphosphate release;    P2 receptors;   

DOI  :  10.3389/fphar.2019.01304

来源: DOAJ

【 摘 要 】

Organs and tissues and their constituent cells are physiologically submitted to diverse types of mechanical forces or stress, one common sequence of which is release of intracellular ATP into extracellular space. Extracellular ATP is a well-established autocrine or paracrine signaling molecule that regulates multiple cell functions and mediates cell-to-cell communications via activating the purinergic P2 receptors, more specifically, ligand-gated ion channel P2X receptors and some of the G-protein-coupled P2Y receptors. The molecular mechanisms that sense mechanical and transduce forces to trigger ATP release are poorly understood. The Piezo1, a newly identified mechanosensing ion channel, shows widespread expression and confers mechanosensitivity in many different types of cells. In this mini-review, we briefly introduce the Piezo1 channel and discuss the evidence that supports its important role in the mechanoregulation of diverse cell functions and, more specifically, critical engagement of ATP release and subsequent P2 receptor activation in Piezo1 channel-dependent mechanoregulation. Such ATP release-mediated coupling of the Piezo1 channel and P2 receptors may serve a signaling mechanism that is more common than we currently understand in transducing mechanical information to regulation of the attendant cell functions in various organs and tissues.

【 授权许可】

Unknown