Antimicrobial Usage and Resistance in Companion Animals: A Cross-Sectional Study in Three European Countries

Antibiotics

JaapA. Wagenaar¹  Dik Mevius¹  Daniela Ceccarelli¹  Haitske Graveland²  Liese Van Gompel³  Andrea Caprioli⁴  Antonio Battisti⁴  Alessia Franco⁴  Philip Joosten⁵  Steven Sarrazin⁵  Jeroen Dewulf⁵  Evelien Odent⁵ 

[1] Department of Bacteriology and Epidemiology, Wageningen Bioveterinary Research, Houtribweg 39, 8221 RA Lelystad, The Netherlands;Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands;Institute for Risk Assessment Sciences, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands;Istituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Department of General Diagnostics, National Reference Laboratory for Antimicrobial Resistance, Via Appia Nuova, 1411, 00178 Rome, Italy;Veterinary Epidemiology Unit, Department of Obstetrics, Reproduction and Herd Health, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium;

关键词: antimicrobial use;    antimicrobial resistance;    companion animals;    critically important antimicrobials;    colistin resistance;    one health;   

DOI  :  10.3390/antibiotics9020087

来源: DOAJ

【 摘 要 】

Companion animals have been described as potential reservoirs of antimicrobial resistance (AMR), however data remain scarce. Therefore, the objectives were to describe antimicrobial usage (AMU) in dogs and cats in three European countries (Belgium, Italy, and The Netherlands) and to investigate phenotypic AMR. A questionnaire and one fecal sample per animal (n = 303) were collected over one year and AMU was quantified using treatment incidence (TI). Phenotypic resistance profiles of 282 Escherichia coli isolates were determined. Nineteen percent of the animals received at least one antimicrobial treatment six months preceding sampling. On average, cats and dogs were treated with a standard daily dose of antimicrobials for 1.8 and 3.3 days over one year, respectively. The most frequently used antimicrobial was amoxicillin-clavulanate (27%). Broad-spectrum antimicrobials and critically important antimicrobials for human medicine represented 83% and 71% of the total number of treatments, respectively. Resistance of E. coli to at least one antimicrobial agent was found in 27% of the isolates. The most common resistance was to ampicillin (18%). Thirteen percent was identified as multidrug resistant isolates. No association between AMU and AMR was found in the investigated samples. The issue to address, regarding AMU in companion animal, lies within the quality of use, not the quantity. Especially from a One-Health perspective, companion animals might be a source of transmission of resistance genes and/or resistant bacteria to humans.

【 授权许可】

Unknown