TRIM8: Making the Right Decision between the Oncogene and Tumour Suppressor Role

Genes

Elisabetta Sbis๠ Apollonia Tullo²  Flaviana Marzano²  Francesca Mastropasqua²  Mariano Francesco Caratozzolo² 

[1] Institute for Biomedical Technologies ITB, CNR-Bari, Via G. Amendola, 122/D-70126 Bari, Italy;Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, IBIOM-CNR, Via G. Amendola, 165/A-70126 Bari, Italy;

关键词: TRIM8;    tumour suppressor;    oncogene;    stemness;    innate immunity;    p53;    NF-κB;   

DOI  :  10.3390/genes8120354

来源: DOAJ

【 摘 要 】

The TRIM8/GERP protein is a member of the TRIM family defined by the presence of a common domain structure composed of a tripartite motif including a RING-finger, one or two B-box domains, and a coiled-coil motif. The TRIM8 gene maps on chromosome 10 within a region frequently found deleted and rearranged in tumours and transcribes a 3.0-kB mRNA. Its expression is mostly ubiquitously in murine and human tissues, and in epithelial and lymphoid cells, it can be induced by IFNγ. The protein spans 551 aa and is highly conserved during evolution. TRIM8 plays divergent roles in many biological processes, including important functions in inflammation and cancer through regulating various signalling pathways. In regulating cell growth, TRIM8 exerts either a tumour suppressor action, playing a prominent role in regulating p53 tumour suppressor activity, or an oncogene function, through the positive regulation of the NF-κB pathway. The molecular mechanisms underlying this dual role in human cancer will be discussed in depth in this review, and it will highlight the challenge and importance of developing novel therapeutic strategies specifically aimed at blocking the pro-oncogenic arm of the TRIM8 signalling pathway without affecting its tumour suppressive effects.

【 授权许可】

Unknown