Promising Approach in the Treatment of Glaucoma Using Nanotechnology and Nanomedicine-Based Systems

Molecules

Huihui Wang¹  FidiniainaRina Juliana¹  Meihao Sun¹  Samuel Kesse²  KofiOti Boakye-Yiadom²  Hanitrarimalala Veroniaina³ 

[1] College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, China;School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China;State Key Laboratory of Modern Chinese Medicine, China Pharmaceutical University, Nanjing 210009, China;

关键词: nanotechnology;    nanomedicine;    drug delivery;    mems;    glaucoma;    intraocular pressure;    imaging;   

DOI  :  10.3390/molecules24203805

来源: DOAJ

【 摘 要 】

Glaucoma is considered a leading cause of blindness with the human eye being one of the body’s most delicate organs. Ocular diseases encompass diverse diseases affecting the anterior and posterior ocular sections, respectively. The human eye’s peculiar and exclusive anatomy and physiology continue to pose a significant obstacle to researchers and pharmacologists in the provision of efficient drug delivery. Though several traditional invasive and noninvasive eye therapies exist, including implants, eye drops, and injections, there are still significant complications that arise which may either be their low bioavailability or the grave ocular adverse effects experienced thereafter. On the other hand, new nanoscience technology and nanotechnology serve as a novel approach in ocular disease treatment. In order to interact specifically with ocular tissues and overcome ocular challenges, numerous active molecules have been modified to react with nanocarriers. In the general population of glaucoma patients, disease growth and advancement cannot be contained by decreasing intraocular pressure (IOP), hence a spiking in future research for novel drug delivery systems and target therapeutics. This review focuses on nanotechnology and its therapeutic and diagnostic prospects in ophthalmology, specifically glaucoma. Nanotechnology and nanomedicine history, the human eye anatomy, research frontiers in nanomedicine and nanotechnology, its imaging modal quality, diagnostic and surgical approach, and its possible application in glaucoma will all be further explored below. Particular focus will be on the efficiency and safety of this new therapy and its advances.

【 授权许可】

Unknown