Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases

Frontiers in Genetics

卷:12

Xiaogang Li¹  J. P. Jose Merlin² 

[1] Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States;

[2] Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States;

关键词: nanotechnology;    nanoparticles;    nanomedicine;    drug delivery;    kidney disease;   

DOI  :  10.3389/fgene.2021.817974

来源: DOAJ

【 摘 要 】

Nanoparticles (NPs) are differing in particle size, charge, shape, and compatibility of targeting ligands, which are linked to improved pharmacologic characteristics, targetability, and bioavailability. Researchers are now tasked with developing a solution for enhanced renal treatment that is free of side effects and delivers the medicine to the active spot. A growing number of nano-based medication delivery devices are being used to treat renal disorders. Kidney disease management and treatment are currently causing a substantial global burden. Renal problems are multistep processes involving the accumulation of a wide range of molecular and genetic alterations that have been related to a variety of kidney diseases. Renal filtration is a key channel for drug elimination in the kidney, as well as a burgeoning topic of nanomedicine. Although the use of nanotechnology in the treatment of renal illnesses is still in its early phases, it offers a lot of potentials. In this review, we summarized the properties of the kidney and characteristics of drug delivery systems, which affect a drug’s ability should focus on the kidney and highlight the possibilities, problems, and opportunities.

【 授权许可】

Unknown