Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma

Cancers

Takahiro Maeta¹  Tsuyoshi Sato¹  Shigeki Ito¹ 

[1] Division of Hematology & Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine, Yahaba 028-3695, Japan;

关键词: CXCR4;    SDF-1α;    multiple myeloma;    drug resistance;    extramedullary disease;   

DOI  :  10.3390/cancers13081793

来源: DOAJ

【 摘 要 】

The C-X-C chemokine receptor type 4 (CXCR4) is a pleiotropic chemokine receptor that is expressed in not only normal hematopoietic cells but also multiple myeloma cells. Its ligand, stromal cell-derived factor 1α (SDF-1α) is produced in the bone marrow microenvironment. The SDF-1α/CXCR4 axis plays a pivotal role in the major physiological processes associated with tumor proliferation, survival, invasion, dissemination, and drug resistance in myeloma cells. This review summarizes the pleiotropic role of the SDF-1α/CXCR4 axis in multiple myeloma and discusses the future perspective in the SDF-1α/CXCR4 axis-targeted therapies in multiple myeloma.

【 授权许可】

Unknown