Pathobiologic Roles of Epstein–Barr Virus-Encoded MicroRNAs in Human Lymphomas

International Journal of Molecular Sciences

Mostafa Ibrahimi¹  Pier Paolo Piccaluga²  Mohsen Navari³  Maryam Etebari³  Lorenzo Leoncini⁴ 

[1] Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-111, Tehran, Iran;Department of Experimental, Diagnostic, and Experimental Medicine, Bologna University School of Medicine, 40126 Bologna, Italy;Research Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh 9516915169, Iran;Section of Pathology, Department of Medical Biotechnology, University of Siena, 53100 Siena, Italy;

关键词: Epstein–Barr Virus;    microRNA;    human lymphoma;    BamHI-A rightward transcript;    BART;    Bam HI fragment H rightward open reading frame 1;    BHRF1;   

DOI  :  10.3390/ijms19041168

来源: DOAJ

【 摘 要 】

Epstein–Barr virus (EBV) is a human γ-herpesvirus implicated in several human malignancies, including a wide range of lymphomas. Several molecules encoded by EBV in its latent state are believed to be related to EBV-induced lymphomagenesis, among which microRNAs—small RNAs with a posttranscriptional regulating role—are of great importance. The genome of EBV encodes 44 mature microRNAs belonging to two different classes, including BamHI-A rightward transcript (BART) and Bam HI fragment H rightward open reading frame 1 (BHRF1), with different expression levels in different EBV latency types. These microRNAs might contribute to the pathogenetic effects exerted by EBV through targeting self mRNAs and host mRNAs and interfering with several important cellular mechanisms such as immunosurveillance, cell proliferation, and apoptosis. In addition, EBV microRNAs can regulate the surrounding microenvironment of the infected cells through exosomal transportation. Moreover, these small molecules could be potentially used as molecular markers. In this review, we try to present an updated and extensive view of the role of EBV-encoded miRNAs in human lymphomas.

【 授权许可】

Unknown