Epstein–Barr Virus in Inborn Immunodeficiency—More Than Infection

Cancers

Sujal Ghosh¹  Ciro Novaes Rosa Lino¹ 

[1] Department of Pediatric Oncology, Hematology and Clinical Immunology, Center of Child and Adolescent Health, Medical Faculty, Heinrich-Heine-University, 40225 Duesseldorf, Germany;

关键词: Epstein–Barr Virus;    EBV;    inborn errors of immunity;    cancer;    lymphoma;    immunodeficiency;   

DOI  :  10.3390/cancers13194752

来源: DOAJ

【 摘 要 】

Epstein–Barr Virus (EBV) is a ubiquitous virus affecting more than 90% of the world’s population. Upon infection, it establishes latency in B cells. It is a rather benign virus for immune-competent individuals, in whom infections usually go unnoticed. Nevertheless, EBV has been extensively associated with tumorigenesis. Patients suffering from certain inborn errors of immunity are at high risk of developing malignancies, while infection in the majority of immune-competent individuals does not seem to lead to immune dysregulation. Herein, we discuss how inborn mutations in TNFRSF9, CD27, CD70, CORO1A, CTPS1, ITK, MAGT1, RASGRP1, STK4, CARMIL2, SH2D1A, and XIAP affect the development, differentiation, and function of key factors involved in the immunity against EBV, leading to increased susceptibility to lymphoproliferative disease and lymphoma.

【 授权许可】

Unknown