High-Mobility Group Box 1 expression predicts survival of patients after resection of adenocarcinoma of the ampulla of Vater

World Journal of Surgical Oncology

Yusuke Izumisawa¹  Itaru Endo²  Yuki Homma²  Takashi Murakami²  Ryusei Matsuyama²  Yasuhisa Mochizuki³  Michio Ueda⁴  Noriyuki Kamiya⁵  Kenichi Yoshida⁶  Tadao Fukushima⁷  Robert M. Hoffman⁸  Keiichi Yazawa⁹  Nobuyuki Kamimukai^1,10  Kunio Kameda^1,11 

[1] Department of Gastroenterological Surgery, Fujisawa City Hospital;Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University;Department of Gastroenterological Surgery, Yokohama Municipal Citizen’s Hospital;Department of Surgery, Gastroenterological Center, Yokohama City University;Department of Surgery, Ito Municipal Hospital;Department of Surgery, Saiseikai Wakakusa Hospital;Department of Surgery, Saiseikai Yokohama Nanbu Hospital;Department of Surgery, University of California;Department of Surgery, Yokohama City Minato Red Cross Hospital;Department of Surgery, Yokohama Hodogaya Central Hospital;Department of Surgery, Yokosuka City Hospital;

关键词: HMGB1;    Adenocarcinoma of the ampulla of Vater;    Overall survival;   

DOI  :  10.1186/s12957-019-1675-8

来源: DOAJ

【 摘 要 】

Abstract Background Expression of High-Mobility Group Box 1 (HMGB1), a multifunctional protein involved in DNA function as well as cell proliferation, inflammation, and the immune response, has been reported to be prognostic in several types of malignancies. However, the prognostic value of HMGB1 in ampullary cancer has not been studied. Methods Patients with adenocarcinoma of the ampulla of Vater who underwent R0 resection with pancreaticoduodenectomy between 2001 and 2011 were included in the present multi-institutional study. The degree of HMGB1 expression was examined in each resected specimen by immunohistochemical staining. Results A total of 101 patients were enrolled of which, 79 patients were eligible. High expression of HMGB1 was observed in 31 (39%) patients. Blood loss, transfusion, tumor stage, nodal status, and HMGB1 expression were identified as predictors with univariate analysis. Multivariate analysis showed that transfusion, lymph-node metastasis, and high HMGB1 expression were independent predictors of poor overall survival. Subgroup analysis showed that high HMGB1 expression was predictive, especially in patients who did not receive adjuvant chemotherapy. Conclusions High HMGB1 expression is an independent predictor of poor prognosis in patients with adenocarcinoma of the ampulla of Vater not treated with adjuvant chemotherapy.

【 授权许可】

Unknown