High Mobility Group Box Protein-1 in Wound Repair

Cells

Elia Ranzato¹  Simona Martinotti¹  Marco Pedrazzi² 

[1] Department of Sciences and Innovative Technology, (DiSIT), University of Piemonte Orientale "A. Avogadro", Viale Teresa Michel 11, Alessandria 15121, Italy;Department of Experimental Medicine (DIMES)-Biochemistry Section, Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV, Genoa 1-16132, Italy;

关键词: HMGB1;    alarmin;    DAMP;    tissue repair;    wound cytokine;   

DOI  :  10.3390/cells1040699

来源: mdpi

【 摘 要 】

High-mobility group box 1 protein (HMGB1), a member of highly conserved non-histone DNA binding protein family, has been studied as transcription factor and growth factor. Secreted extracellularly by activated monocytes and macrophages or passively released by necrotic or damaged cells, extracellular HMGB1 is a potent mediator of inflammation. Extracellular HMGB1 has apparently contrasting biological actions: it sustains inflammation (with the possible establishment of autoimmunity or of self-maintaining tissue damage), but it also activates and recruits stem cells, boosting tissue repair. Here, we focus on the role of HMGB1 in physiological and pathological responses, the mechanisms by which it contributes to tissue repair and therapeutic strategies base on targeting HMGB1.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.