Efficacy of pre-emptive use of cyclooxyenase-2 inhibitors for total knee arthroplasty: a mini-review

Arthroplasty

Jianda Xu¹  Chong Zheng¹  Bin Wang¹  Yuxing Qu¹  Pengfei Shen¹  Zikang Xie¹  Huan Li² 

[1] Department of Orthopaedics, Changzhou Traditional Chinese Medical Hospital, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine;Department of bone and joint, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Suzhou University;

关键词: Cyclooxyenase-2 inhibitors;    Pre-emptive analgesia;    Total knee arthroplasty;   

DOI  :  10.1186/s42836-019-0015-3

来源: DOAJ

【 摘 要 】

Abstract Total knee arthroplasty (TKA) is regarded as the most effective surgery for patients with later-stage arthritis of the knee, but the postoperative pain management for functional improvement of the knew is still a challenging task. This review discusses the mechanism by which the selective cyclooxyenase-2 inhibitors, which reduce the peripheral and central sensitization, decrease pain after TKA. This review also covers the protocols, safety, efficacy, and progress of cyclooxyenase-2 inhibitors in pre-emptive analgesia.

【 授权许可】

Unknown