Effect of pre-emptive analgesia with Gabapentin on post-operative pain relief after total abdominal hysterectomy

International Journal of Biomedical Research

关键词: Gabapentin;    Pre-emptive analgesia;   

DOI  :  10.7439/ijbr.v7i9.3525

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

The study was done to assess the pre-emptive analgesic effect of Gabapentin 300 mg on pain score and analgesic consumption within the first 24 hours after Total Abdominal Hysterectomy under Sub Arachnoid Block. It was a randomized double-blinded clinical trial. A total of 60 consenting female patients aged 30 to 60, belonging to ASA Grade I and II, undergoing TAH were allocated to one of the two groups (Gabapentin & Placebo) of 30 each. Gabapentin group were given Gabapentin 300 mg 2 hours prior to surgery. Surgery was performed under SAB. Post-operative pain was assessed using VAS score and rescue analgesic consumption in the form of Tramadol IV was noted. All patients completed the entire study. The Gabapentin group showed significantly lower VAS scores as compared to the placebo during the post-operative period. The total IV Tramadol consumption was also significantly lower compared to the placebo group during the initial 24 hours following surgery. Pre-emptive use of oral Gabapentin 300 mg significantly reduces the post-operative pain and reduces the rescue analgesic requirement during the initial 24 hours.

【 授权许可】

CC BY