Photothermal scaffolds/surfaces for regulation of cell behaviors

Bioactive Materials

Kunyan Lu¹  Qian Yu¹  Yanxia Zhang²  Yangcui Qu²  Guannan Wang³  Yanjun Zheng⁴  Chaobo Huang⁴ 

[1] the Key Laboratory for Medical Functional Nanomaterials, Jining Medical University, Jining, 272067, PR China;;College of Biomedical Engineering &Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, PR China;State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, PR China;

关键词: Photothermal scaffolds;    Photothermal surfaces;    Tumor ablation;    Intracellular delivery;    Cell detachment;   

DOI  :  

来源: DOAJ

【 摘 要 】

Regulation of cell behaviors and even cell fates is of great significance in diverse biomedical applications such as cancer treatment, cell-based therapy, and tissue engineering. During the past decades, diverse methods have been developed to regulate cell behaviors such as applying external stimuli, delivering exogenous molecules into cell interior and changing the physicochemical properties of the substrates where cells adhere. Photothermal scaffolds/surfaces refer to a kind of materials embedded or coated with photothermal agents that can absorb light with proper wavelength (usually in near infrared region) and convert light energy to heat; the generated heat shows great potential for regulation of cell behaviors in different ways. In the current review, we summarize the recent research progress, especially over the past decade, of using photothermal scaffolds/surfaces to regulate cell behaviors, which could be further categorized into three types: (i) killing the tumor cells via hyperthermia or thermal ablation, (ii) engineering cells by intracellular delivery of exogenous molecules via photothermal poration of cell membranes, and (iii) releasing a single cell or an intact cell sheet via modulation of surface physicochemical properties in response to heat. In the end, challenges and perspectives in these areas are commented.

【 授权许可】

Unknown